I was writing while you posted, Velika. Here is what I was writing.
My mother had several mini strokes. They went undetected for years. Until her personality started to change, she started to forgot things, etc. The symptoms were the same ones a person with early Alzheimer's would show.
Mum did the Alzheimer's tests, it was not Alzheimer's. Then she did more tests. They reveled it was Vascular Dementia, cause by the several ischemic mini strokes. Mum does not have dead eyes nor the circles under the eyes.
And her personality change, when it changes, is not similar to what I have witness with Mr J, my cousin who had MLC or the real life MLCer I know.
As for the evidence, I have my cousin and the former real life MLCers I know. They went back to normal. No more dead eyes, no more circles, or bags, under the eyes.
Mini strokes can be the cause in individual cases, but they are not the cause for most MLCers. If they were, MLCers would not go back to normal.
Do MLCers brain cells die because of their crisis? I do not know. They may. But the reason may be different than interrupted oxygen to the brain because of blockage or rupture or a brain artery.
Grandmother has had serious/big strokes. Her personality did not change, but one of them left her the right side of her body impaired, meaning the stroke was on the brain's left side.
Stokes was one of the things we studied in the neurobiology course. Nothing of what was studied, nor my real live experience with people with both mini and major strokes, and MLC, makes me think the cause of MLC changes is related to mini strokes.
Like I said above, that can be the cause for an individual, but not for MLC as a whole. What we seen happening to MLCers once the crisis is over, as well as several of their behaviours, does not point for mini strokes to be the cause.
There may be a chemical reason behind the shark eyes, but stokes are cerebrovascular accident , they are not chemistry related. They do not happen because of imbalance brain chemicals. Nor because of hormones.
As for the brain itself, one thing we often forget is that the brain also has an eclectic part. The brain has a circuit that is similar to an electric one. Neurons use electrical signs.
The brain is very complex, and there are several issues/illnesses/disorders that can seem one thing and are another. But the main thing to have in consideration with MLC is that, MLCers that come out of crisis go back to normal. That sets it apart from many mental and neurological issues. It makes it more similar to hormonal issues.
Hormonal issues that can cause personality changes, think thyroid, for example, when corrected, will allow a person to go back to normal.
Personally, I can only go with what is observed in most MLCers. Since we are not conducting tests, the one things that stands out in all MLCes is high levels of stress, along with depression. The causes of the depression can be hormonal, imbalanced brain chemicals, etc. The high stress levels is in itself a hormonal issue.
You may indeed have an adverse tetanus booster reaction, Ready2. But nearly ten years have passed. Not sure if the reaction would still be felt so many years after. Do you not need to have a tetanus booster every ten years in the US? Here we do.
Sometimes good things fall apart so better things can fall together. (Marilyn Monroe)