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Author Topic: MLC Monster Biochemistry, neurotransmitters and brain research III

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Smitty2929's husband received testosterone treatment. I'm of the belief that MLC is like COPD in that there are several circumstances that fall under the umbrella, like low T, that affects some but not all MLCers (obviously not female MLCers!). But Smitty's husband was one who benefited from treatment and she saw changes to him from that.

My xH was tested, I believe, for low T, and treatment was not recommended. He has sprouted a ton of body hair during this time, though, so I do believe he has at least seen hormonal changes.

Dr. John Gray wrote a bit about hormone replacement therapy vs. supplementing to increase hormone production in "Venus on Fire, Mars on Ice" that was understandable for a lay person like me. I'd recommend checking it out if you're interested.

For me it is unethical to suggest sneaking drugs and/or supplements to them. As much as I hate what this crisis has done to my life, my xH has free will, and his personal liberties, as unappealing as they are to me, should be respected. I think of my father and how he coughs and loses wind and would benefit from having his lungs checked out, for sure. But he won't do it. He knows he has COPD, but he hates doctors, and feels confident in just cutting back smoking or any of the other home remedies he's got. Will it shorten his life? I have no clue, but I know this is what he prefers, so I don't even pick that fight or try to sneak him to a doctor visit. My xH is lucid, he's not a violent threat, and this is his journey. Leaving them to it could ultimately be better medicine down the line, and without challenging our own integrity.
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V
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R2T, I think she was joking about spiking the food, I'm not even sure testosterone is ingested this way??

Maybe just send them mental "T-vibes."
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I know, OSB. But I still think psychiatrists are often behind the times. Neurologist seem to be, so to speak, the middle of the road. They can both understand the organ and know what a certain behaviour is being displayed without pullling the brain by its roots.

My cousin was helped by my friend who is a psychiatrist. My friend did a good job, but he never requested any tests. Which I found strange. By tests I mean regular things a GP would request, like blood samples to access several basic levels (thyroid, iron, b12, folate, etc), as well as other basic tests a GP would request.

It was interesting because my friend was able to told me Mr J was having a MLC, but he kind of thought my cousin could be bipolar. I told him, no, it is also MLC. The treatment my friend used on my cousin was indeed aimed at bipolar. It worked much better than the treatment that previous pshychiatrists had used.

Cousin was pretty much diagnosed with every single psychiatric disorder in the book, from bipolar to borderline, not leaving aside schizophrenia, psychotic, and something else I forgot. We had been given meds to all those illnesses. And some of those meds cause big harm. Cousin nearly killed himself because of the anti-psychotic meds. The meds for schizophrenia also did not help.

That tends to be a bit my problem with psychiatry (and, sadly, I have some experience with it, since there is mental illness in both sides of my family), often the psychiatrists goes by what is observed and told (by patient and those around the patient) and concludes is X. Or Z. Gives meds for X or Z. They don't work. Then maybe it is H, so lets try meds for H. All this without conducting some basic tests that even a GP would request.

I confess I find it kind of scary. Especially because people with mental illness, be it permanent or temporary, already are in an altered state of mind.

Of course if could be X but it Y also happens in other fields of medicine. But the other fields then to request blood tests, x-rays, CT scans, ultrasounds, MRI's etc. See my aunt. When she first when to the doctor early this year, my looking at her, listening to her complains and physically examine her, the doctor already had some idea of what it was. But he still request a battalion of blood tests, plus ultrasounds and ct scans and a colonoscopy. He did not said "is cancer", you need treatment W, without having the tests results. The person who said it is cancer was actually the surgeon that my aunt went to see afterwards. But that was only after more specific and further tests requested by the surgeon herself.

Like the doctor who first saw my aunt, after seeing my aunt for the first time, the surgeon already had a good idea of what it could be, but it was not said until she was certain and it has been confirmed by many different tests.

Another example. It had become obvious to me some 2 to 3 years ago that my paternal grandmother had Alzheimer's. The behaviour was there, then the meds for Alzheimer's were also there. But I had not tests or medical confirmation. Today I had to talk to one of my paternal cousins because grandmother had took a hit for the worst. My cousin confirmed grandmother's GP had tests with the extension of the brain lesions. The behaviour was there, the meds were there, but the tests also exist.

Here some psychiatric hospitals have patients with dementia. Dementia fall both under the scope of psychiatry as well as neurology, but GPs are often the ones who deal with them, and first detect them, on a daily basis. But, again, for the dementia there are tests. My mother has vascular dementia. She had to do tests before the diagnosed was confirmed. The symptoms and behaviour can be similar to Alzheimer's, but the causes are different.

I prefer what could be called a dual approach, symptoms/behaviour, but also having tests to back up the diagnosis.

I also make a difference between the daily practice of medicine and research, be it on medicine, neuroscience, neurobiology, etc. The former is what is applied on the day to day practice, the second the cutting edge research that is ongoing and that, hopefully, in the future will allow us to be able to tackle many issues, from cancer to Alzheimer's, without forgetting MLC.

Agree, I think MLC will be better understood in the future. Maybe the problem is the name in itself and the stereotypes that are associated with it. A disorder of the mind, with many facets. And an intriguing one, because it mimics other disorders.

And I still think some vitamins and minerals could be of a help. Be it for MLC or non MLC depression. I'm not opposed to meds. Sometimes they are the best and faster option, but I think using vitamins and minerals would also be important. You know how much the B12 is helping you. And me. And several others on the board.

Magnesium is also been helping me a lot, as well as B6, a B vitamin complex, vitamin D and even vitamins A and C. I do feel a huge difference, and not only in the body, in the brain as well.

Today I was able to handle the news about my paternal grandmother well, and what I will next have to do. I was not able to deal well with BD nor with the times after. Why? In the grand scheme of things a spouse having an affair, even being mostering, is less serious than Alzheimer's. Even because one can divorce the spouse.

I think part of my very poor reaction was the huge level of stress I was under. Add to it a couple of serious infections that took me to the ER twice, plus more hurt from my dad's death just days after Mr J left, and it safe to say all my levels where too high or too low. Sadly, I knew nothing about brain/body levels and chemicals, and very little about vitamins and minerals.

Upintheair, I may be better to refrain from putting testosterone on husband's food. It is dangerous playing with hormones, let alone without knowing the person levels. Plus stress (cortisol) affects testosterone, as it affects other hormones and chemicals (to make it easy I'm using hormones and chemicals; hormones are chemicals, but I think it is better understand if they are used separated).

On that bundle of neuroscience and neurobiology books I recently got there was some (two?) that had infos on the teenager brain. Velika's idea is interesting. But, at least for the most part, and to our current best knowledge, an adults brain is different from and adolescence one. The adult have a fully formed brain, the adolescence does not.

However, we do not have brain scans and other tests of the brains of MLCers. We have an idea of what may be going on, but we do not have the tests. At least not on a specific scientific experience conducted to see how the brain is altered during MLC. It would also be important to have the before and after MLC. The before, of course, is a problem, since we do not know who is going to have MLC.

The brain fascinates me, but not only because of MLC. Because of the dementia as well mental illnesses. I also have no troubles to consider possible that several things can contribute to any of those. Or a conjugations of things. Proteins, dopamine, serotonin, cortisol, damages in brain parts, issues with the brain electric circuit, even virus or bacteria. Like OSB said, the brain, as well as humans, is complex, and we are indeed more than the sum of the parts.

As for midlife crisis being about middle life, I don't think a 36 years person is a middle aged person. Mr J was 36 when he left. And he was not the only one who was in his mid, or even early, 30's. His current age would be more middle life fitting.
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Sometimes good things fall apart so better things can fall together. (Marilyn Monroe)

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The updated brain map.  :)

https://www.theguardian.com/science/2016/jul/20/updated-map-of-the-human-brain-hailed-as-a-scientific-tour-de-force

"Researchers reveal that human brain has at least 180 different regions, confirming the existence of 83 known regions and adding 97 new ones".

Lots of areas, and many of them new. That is a lot of research to come.  :)
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Sometimes good things fall apart so better things can fall together. (Marilyn Monroe)

V
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I think I have posted about this before, but wanted to post again about Behavior Variant Frontotemporal Lobe Disorder. I was rereading the description and it really stood out to me as an almost identical description of MLC. It could be that at least some of the cases on the board are this.

Anyhow, for those who are interested:
http://www.theaftd.org/understandingftd/disorders/bv-ftd

Behavioral Variant FTD (bvFTD)

Behavioral variant FTD (bvFTD) is the form of frontotemporal degeneration (FTD) characterized by early and progressive changes in personality, emotional blunting and/or loss of empathy. Patients experience difficulty in modulating behavior, and this often results in socially inappropriate responses or activities. Impairment of language may also occur after behavioral changes have become notable.

Patients typically start to have symptoms sometime in their 50s, though it can occur as early as at age 20 or as late as age 80. As with all FTD, the course of bvFTD will vary from one person to another. Not every symptom will be experienced by every person, nor will these symptoms develop in a pre-ordained sequence.

Key Clinical Features

The hallmark of behavioral variant FTD is a progressive deterioration in a person’s ability to control or adjust his or her behavior in different social contexts that results in the embarrassing, inappropriate social situations that can be one of the most disturbing facets of FTD. People manifest a loss of empathy early in the disorder that is often seen as indifference toward others, including loved ones. Apathy or lack of motivation may also be present. The patient typically does not recognize the changes in his or her own behaviors, nor do they exhibit awareness or concern for the effect these behaviors have on the people around them.

Behavioral symptoms

  • Hyperoral behaviors include overeating, dietary compulsions, in which the person restricts himself to eating only specific foods (such as a certain flavor of Lifesaver, or eating food only from one fast food restaurant) or attempts to consume inedible objects. Patients may consume excessive amounts of liquids, alcohol and cigarettes.
  • Stereotyped and/or repetitive behaviors can include re-reading the same book multiple times, hand rubbing and clapping, humming one tune repeatedly or walking to the same location day after day.
  • Personal hygiene habits deteriorate early in the disease progression, as the person fails to perform everyday tasks of bathing, grooming and appropriate dressing.
  • Hyperactive behavior is exhibited by some patients, and can include agitation, pacing, wandering, outbursts of frustration and aggression.
  • Hypersexual behavior can range from a preoccupation with sexual jokes to compulsive masturbation.
  • Impulsive acts can include shoplifting, impulsive buying and grabbing food off another person’s plate.

Emotional Symptoms

  • Apathy or indifference toward events and the surrounding environment can be marked by reduced initiative, and lack of motivation.
  • Lack of insight into the person’s own behavior develops early. The patient typically does not recognize the changes in his or her own behaviors, nor do they exhibit awareness or concern for the effect these behaviors have on the people around them, including loved ones.
  • Emotional blunting develops early in the course of the disorder, and is manifested as a loss of emotional warmth, empathy and sympathy, and development of what appears to be indifference toward other people, including loved ones.
  • Mood changes can be abrupt and frequent.

Neurological Symptoms

  • Symptoms similar to those seen in Parkinson disease. Among bvFTD patients, the term “parkinsonism” is used to distinguish the fact that they do not have Parkinson disease, though they do exhibit some of these symptoms. Symptoms include: decreased facial expression, bradykinesia (slowness of movements), rigidity (resistance to imposed movement) and postural instability.

    Key Pathological Features

    Patients with behavioral variant FTD may have one of three abnormal protein collections in their brain cells, which can be seen at autopsy: TDP-43, tau, or fused in sarcoma (FUS) protein. See Overview of FTD for details. The bulk of these protein buildups is usually found in the brain areas that have lost the most volume, the frontal and temporal lobes.
    Genetics

    The majority of bvFTD cases have not been linked to genetic mutations.

    Treatment

    As with all forms of FTD, there is currently no cure for bvFTD, and in most cases its progression cannot be slowed. Although no medications have been proven effective specifically in FTD, many clinicians look to the medications and treatment approaches targeting behavioral disturbances as necessary.

    For instance, some FTD patients benefit from selective serotonin reuptake inhibitors (SSRIs, used in treating obsessive-compulsive behaviors, such as hoarding or craving sweets). Clinicians may also recommend antioxidants, such as coenzyme Q10, which are known to slow the progression of damage to brain cells in general, but there is little evidence to support this in frontotemporal degeneration.
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M
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My sister-in-law has bvFTD. I know on paper this sounds similar to MLC and I know how it presents can vary from person to person but this runs in my SIL's family, her mother died from it, two of her sisters also currently have it, and this is nothing like MLC. This is horrible. OK, I know MLC is horrible too, but this is debilitating, it progresses rather quickly, and it's terminal. If the MLCer is still alive and functional after 2 to 3 years, I doubt they have bvFTD.

I sometimes compare my brother's situation and mine. There are similarities. His wife became self-absorbed, non-empathic, her personality changed, but while these changes sound like what happens in MLC, this is a totally different ballgame. And unlike me, my brother knows exactly what the end result will be. Soon my SIL will be going into a nursing home and she'll stay there until she dies within the next few years.

My brother's family is involved in ongoing testing for this condition. It's almost guarenteed that one or more of his children will contract it and it strikes early. My SIL is only 57, like me, she's had this for a little over a year, and it's already reached the point where you can't hold a conversation with her and my brother is afraid to leave her by herself. I went for a run while I was with them last weekend after my SIL wandered off and we didn't know where she went.
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V
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MBIB, I didn't realize when I posted that it is fatal. I had read about this before, but even if MLC is not the same as this, I think that there is some interesting crossover. I know this thread is for people who are interested in the physiological aspect of MLC, and perhaps there are some clues in frontotemporal lobe dementia as to what MLC might be. (Just reading about it ... it sounds like you are witnessing first hand and it is far more extreme.)

I'm so sorry for your brother, and your sister-in-law, and your family.
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Thanks, Velika, and I agree with you. I wouldn't be surprised by frontotemporal involvement in MLC. The similarities are interesting.
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Velika, I too discovered FTD early on and thought I had hit the nail on the head, until I read that it is usually fatal within 5 years.

I came to the conclusion, that MLC must affect those same areas (science already knows that the blood supply decreases to the frontal lobe in depression, and that the longer you leave it untreated, the greater the chance of developing dementia.  Plus inflammation of the brain is also bandied around as being a potential cause).

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I understand the need to find an explanation. I'm the same, trying to understand what's going on. However, by reading bits and pieces of neurology without a deep insight into medicine, neurology, etc., and cherry picking the bits which seem to make sense, we're likely to go wildly off track. Believing MLC= behavioural variant FTD is an example.

I wonder how many people here are qualified to talk about neuroscience? I think there are one or two who have occasionally posted; likewise psychology. I'm not, despite including a significant amount in my PhD (concerned with a specific area: choices). MOOCs and reading are insightful but don't count as qualifications.

Moreover, our spouses have only one thing in common... We believe they are in crisis. They may not think that, neither may a psychologist in some cases. In some cases it's apparent that they are confused, or depressed, etc. In other cases they are stressed but not all of them are.

The sooner we accept that we should focus on ourselves rather than fix our spouses, the better we will be.

This is a good insight:

Quote
if this is biochemical, what is the common thread? What do all of our spouses have in common?

I am not sure that all of our spouses have to have the same biochemical/developmental/ physiological cause.

Let's take something like heart disease. There are many factors that cause heart attack and stroke. Your risk increases with the number of risk factors you have but people can have different factors yet still end up in cardiac arrest.

So, cardiovascular disease can be due to obesity, smoking, genetic history, high cholesterol, high blood pressure, diabetes, stress, lack of physical activity, unhealthy diets and/or harmful use of alcohol. Some young women who take birth control pills will have a stroke.

So, unlike infectious diseases, that have a specific cause, other illness can be due to many factors. We have all heard of an athlete who has a heart attack, often due to heart malformations that were never detected.

So too with our spouses. There have been several possible reasons for their crisis but there is no definitive test to determine what caused such a break in their personality.


Edit fix quote -OP
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« Last Edit: July 30, 2016, 07:04:19 AM by OldPilot »
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