Author Topic: MLC Monster Biochemistry, Neurotransmitters, and Brain Research V  (Read 6158 times)

Offline VelikaTopic starterTopic starter

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MLC Monster Re: Biochemistry, Neurotransmitters, and Brain Research V
« Reply #90 on: January 13, 2019, 05:33:12 PM »
Your logic is circular.

No one here has a spouse that has been "diagnosed" with MLC, yet they have found themselves here with certain cluster of behavior patterns/physical symptoms, so their spouse must have MLC. And even if they have many of the symptoms of other illness, because we all know that they have MLC because they are on a MLC forum, we should not discuss what those illness might be, because we know historically some people on this forum have had their spouses recover/come home so MLC is real and self-correcting.

This makes no sense!

No one at all knows what some, all, or even of one of our spouses truly is experiencing biologically, psychologically, hormonally, or neurologically. We can only guess based on their symptom and compare them to better understood illness.   

MLC is not permanent. It is not a medical diagnosis.

I believe in MLC.

Other diagnoses may in a small number of cases end up being the case but I have not seen one in the 9 years I have been on this site.

Oh I just reread your post and this struck me
Quote
in fact feeds the "midlife crisis" myth


As I said, MLC is NOT a myth. It is very very real and I have seen many spouses return to their marriages...I like discussing MLC on a forum that was created for discussing MLC.

Offline Anjae

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Re: Biochemistry, Neurotransmitters, and Brain Research V
« Reply #91 on: January 13, 2019, 05:40:24 PM »
V, please, not again. We have been there, we got nowhere.
Sometimes good things fall apart so better things can fall together. (Marilyn Monroe)

Offline VelikaTopic starterTopic starter

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Re: Biochemistry, Neurotransmitters, and Brain Research V
« Reply #92 on: January 13, 2019, 06:09:33 PM »
V, please, not again. We have been there, we got nowhere.

Yes, exactly! That is why I posted disclaimer when I shared the article.


Offline VelikaTopic starterTopic starter

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Re: Biochemistry, Neurotransmitters, and Brain Research V
« Reply #93 on: February 02, 2019, 08:07:15 PM »

Offline Anjae

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Re: Biochemistry, Neurotransmitters, and Brain Research V
« Reply #94 on: February 04, 2019, 02:03:41 PM »
https://www.theguardian.com/lifeandstyle/2019/feb/04/stress-anxiety-knees-weak-palms-sweaty

Quite an interesting article on stress, the many health problem long time stress causes and research into the matter.

«“The biggest single risk factor for depression is stress,” says Bullmore. Understanding better this connection could open up new opportunities for treatments targeting immune activity and could even make it possible to intervene before depression occurs in people at risk.»

The article also has an explanation on the role of the three stress hormones: adrenaline, cortisol, noradrenaline and its chemical formula.
Sometimes good things fall apart so better things can fall together. (Marilyn Monroe)

Offline VelikaTopic starterTopic starter

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Offline Anjae

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Re: Biochemistry, Neurotransmitters, and Brain Research V
« Reply #96 on: February 09, 2019, 05:56:06 PM »
Interesting, but, if so, only appliable in the cases described in the article: surgical or medical procedures that reach the eye or neural tissue under certain circunstances.

Or, as the example in the article, people who as children received prion-contaminated human growth hormone that come from cadavers.

As the article says, transmissible does not mean contagious. The article is, essencially, its author making questions. No certainties, as is the case with many neurogolical, and other health/medical issues.

There are several views on what Alzheimer's is, or may be, and how it may originate. It is possible it may originate differently depending of cases. So far, there is no one certainty and no cure. Cure, or, at least, the ability to prevent it from further developing once found, are the most impostant thing.

At a point, I think people come out with too many theories and ideas on many matters, but not with any solution. A bit like with MLC.
Sometimes good things fall apart so better things can fall together. (Marilyn Monroe)

Offline VelikaTopic starterTopic starter

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Re: Biochemistry, Neurotransmitters, and Brain Research V
« Reply #97 on: March 05, 2019, 01:34:48 PM »
Presidential Shark Eyes: 👀

Why are Donald Trump’s pupils intermittently so Dilated?

https://medium.com/@DrGJackBrown/body-language-and-medical-analysis-4221-why-are-donald-trumps-pupils-intermittently-so-large-f4d883c8126a?

You probably haven’t noticed, but President Trump’s pupils are intermittently much larger than normal (the intermittent pattern is crucial). From a medical standpoint, this is not at all subtle or to be dismissed — on the contrary, it is glaring. Sirens Blaring. Red flashing lights.

I write this article with the expertise of both an ophthalmologist as well as a body language expert.

In the image above Trump’s pupils are approximately 8.0 mm. The dark-adapted eyes of a healthy 12-year-old may have 8.0 mm pupils — but in an unmedicated 70-year-old with healthy eyes, in a well-lit room — the statistical odds of such large pupil size approaches zero.

Why is this significant? Dilated pupils, to this degree, would not occur in a 70-year-old, in a well-lit room unless there is either disease, injury or a pharmacologic cause present. Trump’s pupils are frequently but intermittently this large (sometimes they are indeed within normal size limits).

Trump’s enlarged pupils are much less likely a sign of a significant undiagnosed or undisclosed medical condition — and much more likely, a side effect of a drug/medication (one of a relatively small group of drugs).

Pupils react to both Light and Near Focusing — but also change with age

Most people know that exposure to light causes the pupils to constrict. However, you may not know that focusing on an object close up (e.g., when reading) will also cause pupils to constrict. These physiologic findings are normal for all healthy eyes. We cannot medically test for these stimuli (response to a bright light or response to focusing at near) on Donald Trump by evaluating available video or photos — however, at least with response to light, we can make some reasonable estimations.

You also may not realize that, under equal lighting conditions, pupils will become smaller with age. Thus an infant has much larger pupils than a 70-year-old. This change, generally speaking, isn’t very noticeable (for most casual observers) until a person reaches their 30s or 40s — and even then it’s not dramatic. But certainly, this difference is much more noticeable in a 71-year-old.

Donald Trump’s pupils are very frequently larger (often much larger) than they should be for healthy eyes of his age. His pupils are very often as large as they would be if they were medically dilated by an ophthalmologist (with eye drops, such as Tropicamide and Phenylephrine).

As a control, we can compare Trump’s pupils to those who have interviewed him, and are under the same light conditions. In the images immediately above and below, we see Donald Trump and Tucker Carlson during a 15 March 2017 interview.

Trump’s pupils are approximately 5.0 mm in diameter while Carlson’s are 3.0 mm. Carlson is 23 years younger than Trump, thus all other things being equal, Carlson’s pupils under equal light conditions should be larger — not equal, let alone smaller — than Trump’s pupils.

Are Donald Trump’s Large Pupils a complication Cataract Surgery?
This is highly doubtful
Cataracts are an entirely normal aging process. Virtually all 71-year-old people have at least mild evidence of cataracts (and certainly they may be moderate or advanced) and thus many will have cataract development to a degree for which surgery is indicated. And while it’s not entirely clear if Trump has had cataract surgery, some of the available images online are physically close and with high enough resolution to suggest this is the case.

For several decades it’s been considered at least a mild-to-moderate surgical complication to have a permanently dilated pupil (or partially/permanently/poorly reactive pupil) after cataract surgery. This complication can be thought of as a form of micro-trauma to the iris. Such findings are often a signal that other complications also occurred during surgery. While even in the best surgeon’s hands, complications do occur, the likelihood that Trump had this complication in both eyes, is extremely unlikely — because each pupil constricts and contracts — a healthy quality.

Large pupils after cataract surgery often cause a lot of unwanted symptoms (e.g., glare, reflection, increased astigmatic effect, photophobia, etc.). It’s possible that Trump has some of these symptoms, but probably not to any significant degree. Indeed, if the iris is damaged — leaving large pupils after cataract surgery, often a secondary procedure is performed to make the pupil smaller — thus minimizing any of the above-mention symptoms.

Trump’s pupils are equal (or very closely so). And although they are often larger than normal, they do vary in size and are at times “within normal limits”. This finding eliminates surgical complications as a cause of Trump’s often larger pupil size. Pupils damaged as a result of surgery wouldn’t respond in this manner.

In this image, his pupils are 3.5–4.0 mm (the slight difference in his pupil size [known as physiologic Anisocoria] is not significant or medically noteworthy — although certainly if one pupil was much larger or much smaller, it would be very important). So here we see that his pupils ARE indeed ABLE to contract to a smaller size — and this is crucial. But the question is — why are they intermittently so large, so often?

Are Trump’s large pupils due to him deliberate dilating his own pupils with eye drops?
This is highly doubtful
Medications such as Atropine, Scopolamine, Phenylephrine, Tropicamide, Homatropine, and Cyclopentolate are used to dilate pupils for ophthalmic examinations. These are also used to treat certain medical conditions in the eyes. Most notably these include various inflammatory conditions (Iritis, Uveitis, etc.). These conditions will often be correlated with diseases which frequently have serious ramifications for other parts of the body (thus may represent ophthalmic manifestations of systemic diseases).

Occasionally, people will deliberately dilate their pupils so as to feign a medical condition and thus seek attention (Munchausen syndrome). This is an extremely unlikely cause in the case of President Trump’s pupils — for he always tries to present himself as extremely healthy.

Very uncommonly to rarely, a person will inadvertently get a bit of medication or a chemical compound in their eye which will dilate a pupil. There are even species of plants, which, upon gardening and then rubbing one’s eye will have this effect. When this occurs, it will almost always effect only one eye — not both. Again, a long-term observation of Trump’s eyes negates this possibility.

Are Trump’s large pupils due to Trauma?
Highly Doubtful

What about trauma? Could eye or head trauma cause a person’s pupils to be large? Yes — but not in Trump’s case. Since Donald Trump’s pupils change in size over time, and they are round (not irregular in shape) and equal in size — trauma can be eliminated as a cause.

What about a Disease or other Medical Condition?
Below is a list of medical causes of Enlarged Pupils, none of which applies in Trump’s case, for multiple reasons, but in particular because his pupil size changes over time and also would have multiple other associated symptoms with any of these conditions.

Adie’s Pupils, bilateral
Botulism
Cardiac Arrest
Cranial Nerve III (Oculomotor nerves), partial and bilateral,
Diabetes Mellitus
Diphtheria
Encephalitis
Guillain–Barré syndrome
Hypermagnesemia
Hypothermia
Increased Intracranial Pressure
Iris scaring (synechia) secondary to injury or inflammatory disease (Iritis/Uveitis)
Multiple Sclerosis (MS)
Sarcoidosis
Sylvian Aqueduct Syndrome
Syphilis (Neurosyphilis)
Tumors/space occupying lesions
Venom from various poisonous animals (certain snakes, spiders, octopi, and fish)
Wernicke–Korsakoff syndrome

What about Medications/Drugs as a Cause of Trump’s Large Pupils?
This cause is Highly Likely
Are Trump’s large pupils caused by Systemic Drugs? (medications not used in eye drops [as mentioned above], but taken by mouth or by other means) — From a medical standpoint, this is highly probable. Here’s a of list of the possibilities (of course, anesthesia and those labeled with “poisoning” and “overdose” don’t apply):

5-HT2A receptor-mediated psychedelic drugs

5-Hydroxytryptophan

Adrenaline

Amphetamine
Anesthesia (deep general anesthesia or near-total spinal anesthesia)

Antidepressants such as (such as TCAs [overdosage], SSRIs, SNRIs, and MAOIs)

Antihistamine overdose

Barbiturates

Bretylium intoxication

Chlorphentermine

Cocaine

Cyanide poisoning

Dopamine

Ephedrine

Fenfluramine

Glutathimide overdose

Methanol poisoning

MDMA (Ecstasy)

Noradrenaline

Propranolol overdose

Quinine toxicity

Trimethaphan

Tryptophan overdose

Summary: President Donald Trump’s pupils are intermittently and significantly dilated — from a medical standpoint, this is NOT normal. The ambient light conditions cannot account for such changes. At other times they are within normal limits. This intermittent pattern is NOT due to trauma, complications from surgery, or disease. I have not examined Donald Trump and I have no firsthand knowledge of him — however, the myriad of photographic evidence available online seems to point strongly to the remaining possible etiology — Donald Trump’s Intermittently Dilated Pupils are due to the side effects of drugs/medications.

Recent reports by journalist Kurt Eichenwald are consistent with this conclusion.

I invite everyone to refute or confirm these medical findings — particularly those physicians with neuro-ophthalmology expertise.

I also suggest that an independent party set up a publicly available, online photo/video diary to chronologically highlight and monitor President Trump’s pupils.


Offline Anjae

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Re: Biochemistry, Neurotransmitters, and Brain Research V
« Reply #98 on: April 24, 2019, 12:33:05 PM »
https://www.theguardian.com/science/2019/apr/24/scientists-create-decoder-to-turn-brain-activity-into-speech-parkinsons-als-throat-cancer - Scientists create decoder to turn brain activity into speech

Still experimental, but great news.

Sometimes good things fall apart so better things can fall together. (Marilyn Monroe)

Offline VelikaTopic starterTopic starter

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Re: Biochemistry, Neurotransmitters, and Brain Research V
« Reply #99 on: August 14, 2019, 09:25:07 AM »
Fascinating read on electronic brain stimulation, the basal ganglia and nucleus ambens, and personality changes (ranging from mild to severe):

Deep Brain Stimulation
https://aeon.co/essays/is-deep-brain-stimulation-for-better-health-worth-the-risk

Quote
In a small number of cases, stimulation of the subthalamic nucleus (an area of the brain underneath the thalamus that modulates output from the basal ganglia, and which is the preferred target for DBS in Parkinson’s) has been associated with extreme shifts in mood and behaviour, with lives disrupted and derailed.

Affected patients might go on gambling binges and lose their life savings or land in catastrophic debt. In one reported case, a patient’s gambling became so pathological that he had to sell his house to finance his debts; his wife then asked for a divorce, and the patient attempted suicide.

Yet others may become hypersexual and manic. There have been reports of patients who have developed uncharacteristic sexual urges that they feel unable to control. One conservative, mature gentleman began to aggressively insist on sexual gratification every night following DBS treatment. Another report describes a woman who lost all inhibition under DBS, and who began to expose herself to male members of her family, demanding sex.

Other times, changes can be more benign. One patient receiving stimulation to the nucleus accumbens, a part of the forebrain involved in reward and addiction, had not been that much of a music fan prior to DBS treatment. But, under stimulation, he unexpectedly became a devoted fan of the musician Johnny Cash, buying all of his CDs and DVDs, and banning other music that he had previously liked.
« Last Edit: August 14, 2019, 09:26:25 AM by Velika »

 

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