When I did all of my research a few years ago, all of the below (empathy etc) was considered to be regulated by the frontal and prefrontal cortex. (Maybe these areas are now being broken down into smaller parts? I would imagine they would be over time).
The insular cortex is different from the prefrontal cortex. The prefrontal cortex covers the front part of the frontal lobe. The insular cortex is a separated, hidden/isolated one, hence the name, insular. Of course it is not really separated (nothing in the brain is, something always connects to something), that is found on the fold between several other lobes.
http://www.ncbi.nlm.nih.gov/pubmed/22230626 - The insular cortex: a review.
https://en.wikipedia.org/wiki/Insular_cortex - Insular cortex #The insulae are believed to be involved in consciousness and play a role in diverse functions usually linked to emotion or the regulation of the body's homeostasis. These functions include perception, motor control, self-awareness, cognitive functioning, and interpersonal experience. In relation to these, it is involved in psychopathology."
https://en.wikipedia.org/wiki/Prefrontal_cortex - Prefrontal cortex "Many authors have indicated an integral link between a person's personality and the functions of the prefrontal cortex.[1] This brain region has been implicated in planning complex cognitive behavior, personality expression, decision making, and moderating social behaviour.[2] The basic activity of this brain region is considered to be orchestration of thoughts and actions in accordance with internal goals.[3]"
Depression can affect both the insular and the prefrontal cortex (among other parts of the brain). It is hardly ever just one thing that is affected/altered.
Sometimes good things fall apart so better things can fall together. (Marilyn Monroe)