All in all would be interesting to know if any MLCr has started HRT treatment and what the effects were. At least I don't recall reading a single storyline here or other mlc forums where that would have been explored.
Actually, there have been! We used to keep track of that better on some of the old research threads (some go back 10 years or more) that always seem to get buried. Off the top of my head, there was a member named Smitty (with some numbers after it) whose husband got T treatment and improved. They ended up reconciling I think. I'm not seeing her in the member list, but when I search for "Smitty" the name "Battlefield" comes up, so that may be the same person (I'm really not certain).
It's a strong belief of mine that my xH suffered a big andropausal T drop in his mid-30s that contributed to his situation. I remember reading from a reliable source that a drop in estrogen or testosterone doesn't equal an increase in the other, but rather for both it will elevate cortisol, which can cause a ton of problems like anxiety, mental fog, weight gain, etc. I had my 'crisis' right before my xH did, and it aligned with when hormonal birth control (and subsequently going off of it) did a huge number on me, which has taken me years to start to improve from (progesterone being the problem). I had a huge amount of swelling, hair loss, weight changes, and an identity crisis. Fun stuff.
I'm not a huge fan of his books other than this one, but John Gray's "Venus on Fire, Mars on Ice" does a really good job of laying out some of the hormonal and neurotransmitter differences among the sexes and how to naturally improve both. It echoes a lot of our experiences (though most not as drastice) in the parables of the book, so it felt like good research to me years ago when I found it.
https://www.goodreads.com/book/show/7849906-venus-on-fire-mars-on-ice