Johnny Depp, I believe, is entering next stage. BD or the "threshold event" was walking out on his family after becoming obsessed with a young co-star whom he impulsively married then verbally and physically abused. His drinking and spending are out of control, his hygiene is terrible, and he seems unconcerned that his teeth are rotting.
Recent interviews (since last Alice in Wonderland) with him are alarming. He stutters, cannot respond to multi-sentence questions, takes too long to process a question and takes everything literally. His left frontal/temporal lobes are now being affected, the language center. I think he is embracing his "rock-star" musical side now to compensate for atrophy in the speech center.
Ben Affleck and Anthony Lapaglia are a few years behind Depp. Just look at all of their dead eyes, the window to the soul.