This, as ever, is a most interesting discussion.
I agree that we can get very excited by anything that publicly acknowledges that MLC, and crises like it, is "real", in whatever way -- biochemistry or anything. And I think that's OK -- I like the fact that it would help all of us understand what otherwise is just completely bewildering.
I also agree with the bit about alterered perceptions of reality. A number of us have written here that we, ourselves, have experience of depression in various degrees, I know from my own experience that depression completely alters perception of the world, and things really truly do seem very different from what they are, or rather what they are when my own mind is "normal".
And speaking of menopause, that certainly can affect women very, very differently. I've been lucky, in that it actually seems to have improved many mood issues, but I know women who have been severely affected in a very negative way, and even if they recognise that that is what is happening, they struggle mightly to deal with the effects, both physical and mental. The mental ones most. And I know one who has struggled for over 10 years, it's never been "over" for her, and I understand that other female relatives of hers also had that problem.
And oh, my goodness, if there were a way to shorten/mitigate her menopause she certainly would have done it!
I also have a teenage son with a number of learning difficulties, and yes, he does well in one subject but not in the others. He doesn't choose that -- he really struggles. He pours his all into his school day, and simply has nothing left when he gets home. He is angry at that, angry at H, the anger ends up coming out in all sorts of ways. He needs to feel safe, and he needs help to learn how to deal with and control those strong emotions.
This same S, by the way, is currently saying that his father is doing what he is doing to piss HIM (S) off....